Edelstein is known for playing Dr. Lisa Cuddy on the Fox medical drama series House. Her father is a pediatrician at Chilton Memorial Hospital since retired.
At 16, Edelstein was a cheerleader for New Jersey Generals.
Edelstein encountered trouble when she organized a protest because the team was forcing the cheerleaders to stand in bars while wearing their uniforms. Edelstein said she felt they were treated "like hookers" and organized a cheerleader walkout.
Jameswho briefly refers to Edelstein in his book Disco After being dubbed a " celebutante " by The New York Times magazine during her club kid days,  Edelstein used her new-found celebrity to write, compose and star in an original musical called Positive Me  in response to the growing AIDS crisis of the s.
On Sports Nightshe played a sports reporter who claimed to be a former lover of Josh Charles 's character whom he did not remember. From toshe portrayed her biggest and most notable role to date, Dr.